a School of Health SciencesHES-SO Valais/Wallis; University of Applied Sciences and Arts Western Switzerland
b FORS, Swiss Centre of Expertise in the Social Sciences, University of Lausanne, Expert in Database Processing
c Service of Old Age Psychiatry, Lausanne University Hospital
d University of Lausanne, Research Center for Psychology of Health, Aging and Sport Examination
e Research Center for the Psychology of Health, Aging and Sports Examination, University of Lausanne, Lausanne, Switzerland, and President of the Association for European Qualitative Researchers in Psychology (EQuiP)
f Higher School of Nursing of PortoInstitute of Biomedical Sciences Abel Salazar, University of Porto
A substantial proportion of older adults suffering from multiple chronic conditions are frequently treated with complex medication regimens . When five or more medications are taken daily, this is commonly known as polypharmacy. Although polypharmacy may be clinically appropriate, polymedicated older adults with multiple chronic conditions are susceptible to medication-related problems, including adverse drug reactions, medication errors and non-adherence, which can result in emergency department visits and hospital admissions/readmissions . Because optimal medication management is one of the conditions necessary for home-dwelling older adults to remain at home and preserve their quality of life, identifying individual profiles presenting a greater risk of medication-related problems and adverse health outcomes is imperative . The underlying mechanisms explaining associations between medication-related problems and polymedicated, home-dwelling, older adults’ emergency department visits and hospital admissions/readmissions remains underexplored. To fill this gap, the first phase of the ME@home project aimed to investigate factors leading to MRPs and adverse health outcomes, including 30-day hospital readmissions and unplanned institutionalisation among this population.
We carried out a longitudinal, registry-based study of the hospital record of polymedicated, home-dwelling, older adults using data from 1 January 2015 to 31 December 2018. This four-year, registry-based dataset included polymedicated inpatients (five or more medications prescribed at hospital discharge), aged 65 years old or more, living in their own homes, and hospitalised at least once at the Valais Romand Hospital Centre, composed of five hospitals, in a French-speaking region of Switzerland. The dataset comprised 140 variables routinely collected during hospital stays, including patients’ sociodemographic characteristics, medical and surgical diagnoses, and routinely assessed clinical data (such as gait, balance disorders, fall risk, hearing, concentration or ability to learn). Medical and surgical diagnoses were coded based on the International Classification of Diseases version 10 (ICD-10)  and Switzerland’s surgical intervention classification (CHOP) . Multivariate logistic regressions were computed to explore the risks of adverse health outcomes, such as 30-day readmission and unplanned institutionalization. Ethical approval from the Human Research Ethics Committee of the Canton of Vaud (CER-VD-2018-02196) allowed the hospital’s data warehouse to provide the appropriate dataset.
The raw dataset was extracted from the hospital registry into a statistical package for cleaning, customisation, and synthesis , and it covered 20,422 electronic records the inpatient stays of of polymedicated, home-dwelling, older adults. Different clustering methods, expert opinion, recoding and missing-value techniques were used to customise and synthesise this multidimensional dataset. Seven clusters of medical diagnoses, surgical interventions, and somatic, cognitive and medication data were extracted using empirical and statistical best practices. Each cluster presented the health statuses of the patients included as accurately as possible. Medication classifications were computed based on the World Health Organization Anatomical Therapeutic Chemical (ATC) classification system . This overall approach provided a population-based database suitable for analysing descriptive, predictive and survival statistics.
Thirty-day readmission risk
The customised hospital register was used to investigate the 30-day hospital readmission risks related to separate medical diagnoses and prescribed medications. The subset of readmitted inpatients included 13,802 hospital stays, between 2015 and 2018, involving 8,878 different individuals by older adults who returned home and had no missing data. The 30-day hospital readmission rate was 7.8%. Hospital length of stay (Mean ± standard deviation 8.44 ± 7.58; odds ratio [ OR] 1.01), multimorbidity (0.58 ±0.92; (OR = 1.42 per additional ICD-10 condition), functional impairments (7.8% vs 7.2%; OR 1.22) and number of prescribed medications (8.95 ± 3.24; OR 1.04 per additional medication prescribed) were significant factors in predicting hospital readmission. The risk was also increased when using certain specific drugs, including antiemetics and antinauseants (OR 3.216 per additional drug unit taken, 95% confidence interval [CI] 1.842–5.617), antihypertensives (OR 1.771, 95% CI 1.287–2.438), drugs for functional gastrointestinal disorders (OR 1.424; 95% CI, 1.166–1.739), systemic hormonal preparations (OR 1.207, 95% CI 1.052–1.385), vitamins (OR 1.201, 95% CI 1.049–1.374) and the concurrent use of beta-blocking agents and drugs for acid-related disorders (OR 1.367, 95% C: 1.046–1.788).
With the available clinical, medical, and drug data, the customised hospital dataset allowed us to investigate 14,705 hospital stays, between 2015 and 2018, by older adults with no missing data who had not died during hospitalisation (N = 14,705). These cases involved 9,430 different individuals, with an average of 1.56 hospital stays per person.admissions from 2015–2018 associated with unplanned institutionalization. The mean prevalence of unplanned institutionalisation (UI) after hospital discharge was 6.1%. Patient-related risk factors leading to institutionalisation were declines in physical function (OR = 3.22; 95% CI 2.67 to 3.87) and cognitive function (OR = 3.75; 95% CI 3.06 to 4.59). In addition, the number of prescribed medications (RH: 8.9.1; UI: 10.9; OR 1.17 per additional drug prescribed; 95% CI 1.15 to 1.19), antiemetics/antinauseants (OR = 24.5357; 95% CI 12.2190 to 57.30), psycholeptics (OR = 1.76; 95% CI 1.60 to 1.93), anti-Parkinson drugs (OR = 1.40; 95% CI 1.12 to 1.75) and antiepileptics (OR = 1.49; 95% CI 1.25 to 1.79) were strongly linked to unplanned institutionalisation.
Perspectives for future research and practice
Our transformed, customised dataset delivered an usable, population-based database suitable for advanced analyses relating to polymedicated, home-dwelling, older adult inpatients. Our results highlighted that patient-, medication- and environment-related risk factors could all lead to 30-day hospital readmission (or institutionalisation). Further research is required, however, across larger samples of older adult inpatients to investigate whether tailored interventions at early stages in chronic diseases could delay physical and cognitive dysfunction and decline, and prevent adverse health outcomes among this growing population segment.
Reihe: Projekte des Nationalen Forschungsprogramms NFP 74 «Smarter Health Care»
Der vorliegende Text fasst die wichtigsten Ergebnisse des Projekts Nr. 34 « Das Medikamentenmanagement für ältere Menschen, die zu Hause leben, sicherer machen» von Dr. Henk Verloo vom Institut Santé & Social, HES-SO/Valais zusammen.
Dieses Projekt ist eines von insgesamt 34 geförderten Projekten des NFP 74 des Schweizer Nationalfonds. Ziel des NFP 74 ist es, wissenschaftliche Grundlagen für eine gute, nachhaltig gesicherte und «smarte» Gesundheitsversorgung in der Schweiz bereitzustellen. Informationen: nfp74.ch
This study was supported by the Swiss National Science Foundation via grant number 407440_183434/1.
The authors report no conflict of interest surrounding this work.
Adresse de correspondance
For the project:
Dr. Henk Verloo PhD, Full Professor
School of Health Sciences
HES-SO Valais / Wallis; University of Applied Sciences and Arts Western Switzerland
5, Chemin de l’Agasse
CH-1951 Sion, Switzerland
For the programme:
Verantwortlicher Medienarbeit des NFP 74 www.nfp74.ch
1. Cherubini A, Laroche ML, Petrovic M. Mastering the complexity: drug therapy optimization in geriatric patients. Eur Geriatr Med. 2021 Jun;12(3):431–4. http://dx.doi.org/10.1007/s41999-021-00493-5 PubMed
2. Lea M, Mowe M, Mathiesen L, Kvernrød K, Skovlund E, Molden E. Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. PLoS One. 2019 Jul;14(7):e0220071. http://dx.doi.org/10.1371/journal.pone.0220071 PubMed
3. Linkens AE, Milosevic V, van der Kuy PH, Damen-Hendriks VH, Mestres Gonzalvo C, Hurkens KP. Medication-related hospital admissions and readmissions in older patients: an overview of literature. Int J Clin Pharm. 2020 Oct;42(5):1243–51. http://dx.doi.org/10.1007/s11096-020-01040-1 PubMed
4. World-Health-Organization. International Statistical Classification of Diseases and Related Health Problems (ICD). 2021 [cited 2021 January 20]; Available from: https://www.who.int/standards/classifications/classification-of-diseases
5. Surgical interventions clasification, S., Swiss classification of surgical interventions (CHOP). 2016.
6. Taushanov Z, Verloo H, Wernli B, Di Giovanni S, von Gunten A, Pereira F. Transforming a Patient Registry Into a Customized Data Set for the Advanced Statistical Analysis of Health Risk Factors and for Medication-Related Hospitalization Research: Retrospective Hospital Patient Registry Study. JMIR Med Inform. 2021 May;9(5):e24205. http://dx.doi.org/10.2196/24205 PubMed
7. WHO. The Anatomical Therapeutic Chemical Classification System with Defined Daily Doses (ATC/DDD). 2014; Available from: http://www.who.int/classifications/atcddd/en/
Published under the copyright license
“Attribution – Non-Commercial – NoDerivatives 4.0”.
No commercial reuse without permission.